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Interaction with a GABA B R2 through each partners C-terminal coiled-coils masks the retention motif, thus allowing surface expression of the heterodimer

Indeed, many of these side effects are potentially devastating for patients, especially when combined with other comorbidities or other side effects

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Arendt-Nielsen L, Morlion B, Perrot S, Dahan A, Dickenson A, Kress HG, et al