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One study proposed that SCFAs exert their effects on leukocytes and endothelial cells via two known mechanisms, i.e., activating GPR41 and GPR43 and inhibiting the histone deacetylase (HDAC) activity (Vinolo et al., 2011)

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Stable-isotope tracing: In-vivo [U- 13 C]serine intraperitoneal injection Food and water were withdrawn for 5 hours starting within the first hour of the light cycle

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Cardiometabolic risk factors, such as C-reactive protein, lipids, and blood pressure, were also reduced with semaglutide treatment compared with placebo [49]