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NMDA receptors requirement for coincidence detection to activate and ability to flux calcium ions makes the NMDA receptor integral to synaptic plasticity, and NO co-transmission is intimately coupled to NMDA receptor activity in this context (Hansen et al., 2017)

For a fuller picture, the dedicated article on L-arginine side effects and safety covers what to watch for in specific populations

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Exposure to temperatures above 25C/77F during transport and storage will lead to minor losses in moisture content

However, that threshold is based on testosterone studies of older men, and overlooks the normal age-related decline in testosterone levels

PMID: 26030851