& Burdorf, A
Steady state studies varying NADPH and inhibitor concentrations indicate that treatment with the fast inhibitors 7 and 8 or the slow inhibitor 3 , (the only slow inhibitor reaching equilibrium in 6 h), resulted in decreases in both K m and V max values consistent with uncompetitive inhibition of TGR, while treatment with 9 , a close analog of compound 8 synthesized ad hoc to facilitate structural studies (see below), changed only the V max indicating noncompetitive inhibition (Supplementary Tables 15 and 16)
Funding We thank the following institutions for funding the project: Research Foundation Flanders, G0E416N, G.0C76.18 N, G.0B7.18 N, G.0B96.20 N, G049720N, G.0A93.22 N (TVB, PV)
Kathy Hochul delivered her 2025 State of the State Address
Bacteriostatic water versus sterile water Sterile water is exactly what it sounds like
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