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J Membr Biol 89:18 Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N (1992) Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat

Other adaptive mechanisms of the respiratory tract to cigarette smoke-related oxidative stress include increased glutathione synthesis and decreased cystic fibrosis transmembrane conductance regulator (CFTR) activity, both of which have been observed in healthy smokers

REDEFINE clinical trial program: Safety and efficacy data

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The clinical trials that showed disappointing results used oral administration