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The New England Journal of Medicine commentary accompanying SURPASS-2 stated: "The dual incretin approach appears to exploit receptor crosstalk in ways that amplify downstream insulin secretion beyond what GLP-1 receptor agonism alone can achieve at comparable tolerability." [30] SURPASS-1: Monotherapy Benchmark SURPASS-1 (N=478) established monotherapy efficacy, with tirzepatide 15 mg reducing A1C by 2.07 percentage points and body weight by 9.5 kg at 40 weeks versus placebo [31]

8 A prospective cohort study involving seven psoriasis patients with type 2 diabetes treated with liraglutide for 12 weeks observed a mean PASI decrease from 15.7 to 2.2 and a DLQI improvement from 21.8 to 4.1.9 Additionally, reductions in HbA1c, BMI, and waist circumference were observed.9 One randomized, placebo-controlled trial involving 20 obese, glucose-tolerant patients with plaque psoriasis, however, found no significant improvement in PASI after 8 weeks of liraglutide

Leuk Res (2012) 36(8):96673

Kuriyan, R

10.1006/bbrc.2002.6541 Biochem