What to measure Because the expected changes are modest, rely on body composition measures not just scale weight
(5) Drug Particle Size Distribution (DPSD) by cascade impactor for suspension nasal sprays only, measuring the actual drug particle size
Regulatory bodies like the FDA and EMA necessitate thorough physicochemical characterisation, stability information, and proof of therapeutic equivalency, which can be challenging for these heterogeneous systems [124]
To deliver 50mcg at 333mcg/mL, draw 0.15mL (15 units) instead of 0.1mL (10 units)
Animal studies using diet-induced obese mice found 5-Amino-1MQ administration increased NAD+ levels by approximately 4060% in adipose tissue and improved glucose tolerance without changes in food intake
The key is monitoring body composition with DEXA scanning so you know what you're actually losing