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Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day
Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)
More pronounced in patients whose baseline decline was significant before starting
Br J Pharmacol (2016) 174(12):178496.10.1111/bph.13544 2 HaddadJJHarbHL
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