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GIP has also been found to exert influence over other tissues such as bone, although its extraglycemic profile is quite limited and largely pre-clinical in nature compared to its much celebrated partner GLP-1 [13]

There is a dose relationship with risk for adverse events with ibuprofen and other NSAIDs, which are generally well tolerated at lower OTC doses

Laboratory evaluation typically includes complete blood count to assess for anemia and determine acuity of blood loss, comprehensive metabolic panel to evaluate renal function and electrolytes (particularly relevant given tirzepatide's gastrointestinal effects), and coagulation studies if bleeding disorder is suspected

Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on July 14th, 2025