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But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater

All four pairs of BsNbs exhibited the corresponding BsNb peak in chromatogram, and the conjugation efficiency was greater than 50% (Table S5)

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In particular, nanoliposomes stand out due to their high biocompatibility, biodegradability, and intrinsic ability to cross the BBB, positioning them as a highly effective drug delivery platform with significant potential for applications in translational medicine 37