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This study further revealed that AS-IV can limit NF-B nuclear translocation in high-glucose-stimulated GMCs by upregulating Nrf2 and reducing ROS generation, subsequently downregulating inflammatory markers like MCP-1, TNF, IL-1, IL-6, and fibrosis markers Fn and Col IV downstream of NF-B, thereby ameliorating GMC inflammation and fibrotic damage under high glucose (Su et al., 2023)

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moreover, a meta-analysis of previous randomized trials showed a reduction in total cancer mortality with supplementation (68)

A notable approach involves the development of NLCs co-loaded with methotrexate (MTX) and baicalin, aiming to improve skin permeation and therapeutic outcomes

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2) NLRP3 inflammasome activation, triggered by Tat, gp120, and viral RNAs, which is exacerbated by ROS, ion flux changes, and impaired autophagy, with NF-B acting as a crucial priming signal for pyroptosis and pro-inflammatory cytokine release