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RIG-I, retinoic acid-inducible gene I

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We then excluded compounds that are not yet approved for human use, have potential toxicity issues, were never marketed, or were not known to cross the bloodbrain barrier

PMID 18596934

Duration depends on your goals: postinjury or postsurgery protocols might last 816 weeks, while chronic wearandtear cases may benefit from longer courses with periodic reassessment

Immune Dysregulation and Sustained Inflammatory Signaling Repeated exposure can sustain immune activation beyond its normal protective role