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The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands

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doi: 10.3389/fnmol.2016.00004 Received 07 September 2015 Accepted 07 January 2016 Published 26 January 2016 Volume 9 - 2016 Edited by Ashok Hegde, Georgia College & State University, USA Reviewed by Fred J

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