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People who prefer this approach over synthetic hormone replacement often gravitate toward sermorelin and similar hormone-balancing peptides

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Key drivers included dissatisfaction with treatment frequency and perceived lack of clinician knowledge, with 80% citing improved quality of life as their primary motivation for self-injecting [26]

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Dehydration represents an important factor, as GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation, leading to volume depletion