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After synthesis, each peptide component undergoes HPLC purification to confirm chromatographic purity and mass spectrometry analysis for precise molecular weight verification

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Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]

The human data we have comes from small pilot studies and retrospective case series, most of which were conducted at private clinics

Nephron Exp Nephrol 98:e5560 Chaiyarit S, Thongboonkerd V (2022) Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation