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Epidemiological studies have shown that prenatal infection combined with trauma exposure during prepuberty significantly increases SCZ risk compared to either factor alone, especially in boys (Debost et al., 2017)

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To enhance interpretability despite this variability, we pooled outcomes within instruments (HDRS, BDI, MADRS), conducted prespecified subgroup analyses by comparator group and age, used random-effects models, performed leave-one-out sensitivity analyses and publication-bias diagnostics, and applied meta-regression to examine treatment duration and daily dose

Vitamin B12 (Methylcobalamin or Cyanocobalamin): Essential for red blood cell production, neurological health, and energy metabolism