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The PREDIMED trial, which enrolled thousands of older adults at cardiovascular risk, demonstrated that MD adherence may improve memory and executive function and potentially delayed progression to mild cognitive impairment (204)

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Using various biochemical and biophysical approaches, we demonstrate that Syn WT engages in functional interactions, whereas C-terminal acidic tail truncated Syn 1103 and S129-phosphomimicking ( S129E ) mutant are reactive, displaying broad, non-functional aberrant binding and impairing chaperone-mediated refolding