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A suggested rate of weight loss is 0.5 2 pounds/week (Schweitzer 2026)

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Some individuals carry genetic variants associated with higher or lower baseline GLP-1 receptor expression, which may affect medication efficacy and the likelihood of sustained weight loss

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Under these conditions, retatrutide still about doubled FOC (increase by 289% after 100 nM compared to force before retatrutide, or from 2.01 0.33 mN to 7.29 1.05 mN, n = 8)