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Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor
is grateful to the Austrian Science Fund FWF (Austria) for grants P23490-B20, P29262, P24381, P29203 P27893, I1000, and SFB Lipotox (F3012), as well as to Bundesministerium fr Wissenschaft, Forschung und Wirtschaft and the Karl-Franzens University for grant Unkonventionelle Forschung and grant DKplus Metabolic and Cardiovascular Diseases (W1226)
doi: 10.1111/jam.12273 260 DuanTDuYXingCWangHYWangRF
TM's ability to lower free copper levels is exploited in the treatment of Wilson's disease, a genetic disorder characterized by copper accumulation in tissues responsible for hepatic and neurologic disorders
Balla, A