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A) mice administered Dihexa through a cannula, B) mice administered Dihexa via intraperitoneal injection, and C) mice administered Dihexa via oral delivery methods 2) In order to determine whether AngIV is involved in the development of Alzheimers, the research team of Sun et al detected the baseline levels of AngIV in both wild type and APP/PS1 mice

Int J Mol Sci 21:8767

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Finch NC, Syme HM, Elliott J

10.1016/S2213-2600(16)30044-3 Lancet Respir Med

Moreover, several studies have demonstrated that the metabolic transition from OXPHOS to aerobic glycolysis mediated by Akt-mTOR-HIF-1 is the metabolic basis of TI (102, 116, 117) ( Figure 3 )