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As discussed above, elevated circulating TMAO levels correlate with a higher risk of adverse cardiovascular events

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DOI: 10.1016/S0140-6736(19)31150-X [Google Scholar] Martinez Leon V, Hilburg R, Susztak K

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Severe hypoglycemia was not reported, and gastrointestinal events were the most frequent adverse effects in the tirzepatide group ( Tirzepatide was compared to once-weekly oral semaglutide in the SURPASS-2 study, an open-label, phase 3 clinical trial with a 40-week follow-up that enrolled T2DM patients with a BMI of 25 kg/m 2 and an HbA1c of 710.5% despite taking at least a 1500 mg dose of metformin