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Summary: Retatrutide is an unlicensed investigational triple agonist associated with dose-dependent increases in resting heart rate, though dedicated cardiovascular outcomes trial data are not yet available

For example, Khorasaniha et al

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GLP-1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF-kappaB signaling pathways in streptozotocin-induced diabetic rats

Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

this is due to riboflavin and its metabolites, and it is a harmless effect