10.1002/ptr.5640 204 VileG
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Chronic hyperglycaemia leads to metabolic adaptations in many cells, aiming to reduce glucose transport and to maintain intracellular glucose concentrations within the physiological range 5,6
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This makes your pancreas unable to produce enough insulin, a hormone that regulates blood sugar levels, making your cells slow down their sugar intake, leaving a lot of sugar to circulate in your bloodstream
However, mechanism does not automatically determine timing