Q., Hewetson, A., Muthusubramanian, A
De Strooper, B
Filipinos looking for long-term, culturally integrated health solutions
Hours 24-48: 41% report "starting to feel different," described as "less heavy," "clearer thinking," or "easier to get out of bed." Hours 48-72: Peak onset window
In vivo , the enriched immunoreactivity or transcription of the GLP-1R was detected in neurons of the DVC, paraventricular and posterior thalamic nuclei, various hypothalamic regions, ventral, posterodorsal and interpeduncular tegmental areas, the periaqueductal gray and superior colliculus, while medium to low levels of GLP-1Rs were found in the posterior/caudal hippocampus, the hippocampal CA1, temporal/cerebral cortex, striatum, substantia nigra (SN) [which included tyrosine hydroxylase (SN)-expressing dopaminergic neurons (Elabi et al., 2021)], locus coeruleus, preoptic area, parabrachial nuclei, lateral septum, lateral habenula
.jpg)
Made of 3 amino acids: glutatemic acid, glycine and cysteine Our body bonds them by using an enzyme called glutathione synthase Other enzymes use glutathione as an antioxidant With age we decrease the amount of glutathione we make Because its made in our cells, there is no way to transport those three things into our cells by taking it orally pointless UNLESS Liposomal Only one with a chance of potentially valuable Liposomal Glutathione Can bypass transport rules and get into cells Not many studies, some animals have shown some get into the brain, but at a dose wayyyy higher than you can take/afford Usually available at 100-400mg/dose and very expensive You may get some in your brain, but not sure how much you get Only tries to solve half the problem as the enzymes that use glutathione also decrease with age, so just getting more glutathione in your body, doesnt mean you can use it 2014 study on TBI with mice and found that if they directly added glutathione to a mouse brain within 3 hours, they prevented like 70% of the damage (not human study) Ongoing studies to see what can be done with humans Other ways to increase glutathione : Tumeric: Common in curries (a spice) Circumin: gets into brain, antioxidant alone and turns on glutathione genes and the entire glutathione system Rapidly metabolized which activates a pathway in a liver to metabolize asap so not very usable Piperine in black pepper can slow this metabolism down and increase bioavailability of circumin (and lots of other things) in the body by 2000x There would be a concern that this could impact the half-life of other medications/supplements you are taking be cautious Tumerone , also in turmeric that does a lot of similar things to circumin and repairs brain damage by proliferation of neural stem cells in the subventricular zone (mouse study in 2014) Still unclear at what dose and if could work at all in humans (trials ongoing ) DHA/EPA are key for the brain health and people look to Fish/Krill oil for supplementation Krill Oil vs
