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Additionally, peptide DSIP has been shown to interact with the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in stress adaptation and immune function

1 and ESM Table 5)

Furthermore, a retrospective study of 147 lung cancer patients with MET exon 14 mutations revealed a 17% ORR and a mPFS of just 1.9 months post-immunotherapy [122]

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Human anti-inflammatory trials with glutathione supplementation are limited, though the NAC-glutathione connection provides indirect clinical support

Clinical Evidence and Impact on Diabetes Multiple randomized controlled trials have documented that GLP1 receptor agonists not only enhance glycemic control but also lead to meaningful weight reduction