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Symptoms typically diminish as gastrointestinal side effects resolve and patients establish adequate nutrition and hydration patterns

Proposed Treatment Current KP treatments on the market all use similar keratolytics: Urea, Alpha Hydroxy Acids (AHA), or Beta Hydroxy Acids (BHA) to help chemically exfoliate the infundibular plug, reducing the bumpy texture

Rebalance address the lifestyle inputs that decide whether the barrier holds: an anti-inflammatory diet, stress, sleep, and the circadian factors that influence gut function

Have systems for reporting adverse events, following manufacturers and FDA requirements

Medical supervision is critical as side effects like nausea and diarrhea are common with GLP-1 use, and the drugs are linked to rare risks like pancreatitis

S3 and Table S1a