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Yes, injections are more effective for people who cannot absorb B12 properly, as they bypass the digestive system and deliver the vitamin directly into the bloodstream
Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
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It is recommended to frequently monitor blood levels of potassium and platelet counts in these individuals for early detection and appropriate management of any abnormalities
If poisoning occurs, contact a doctor or the Poisons Information Centre
Heavy alcohol consumption can also contribute to this deficiency
