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No new safety signals were observed

But could there be another explanation

Contact your healthcare provider promptly if you experience any of the following after injection: significant swelling or hardness at the injection site that does not resolve within 48 hours, redness that expands beyond two inches from the injection point, warmth or heat radiating from the injection site combined with pain, any discharge from the injection site including pus or cloudy fluid, fever following injection, severe allergic reaction signs including hives or difficulty breathing, or persistent pain that intensifies rather than improving over 24 hours

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But if I wanted to, I could use smaller doses

In mice, the activity of STAT3 DNA binding was observed within 30 min and peaked 3 h after PHx ( The PI3K/Akt pathway plays a vital role in regulating cell growth, migration, differentiation, and apoptosis (Vanhaesebroeck et al., 1999)