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Performing a pathway-enrichment analysis of the 189 significant sites from the DIA dataset revealed the EGFR1 signaling pathway as the most significantly overrepresented pathway ( p = 1.57E-11 and BenjamiHochberg correct p = 6.06E-09) among the 746 distinct pathways covered (Supplementary Data 4)
Patients may present diverse symptoms and endoscopic manifestations, along with an inflammatory response of varying severity
[69] ) Mutations in a wide range of other genes do not by themselves cause SLE, but two or more of them may act together, act in concert with environmental factors, or act in some but not other populations (e.g., cause SLE in Chinese people but not Europeans) to cause SLE or an SLE-like syndrome, or do so in only a small percentage of cases
Discussion In multi-omics studies, analyzing individual samples enables exploration of individual-level variability and supports robust statistical inference [24]