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Hallmark deficiency syndromes include: Thiamin deficiency leading to beriberi or WernickeKorsakoff syndrome Niacin deficiency causes pellagra (dermatitis, diarrhea, dementia) Folate deficiency leading to megaloblastic anemia and increased birth defect risk Vitamin C deficiency causes scurvy More subtle early warning signs across several vitamins include fatigue, glossitis (inflamed tongue), cracked lips, brittle hair and nails, easy bruising, and recurrent infections, which indicate a weakened immune system
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doi: 10.1007/s13300-020-00786-1
This destructive oxidative process is considered a central mechanism of ferroptosis, iron overload accelerates the production of ROS via the Fenton reaction, which in turn amplifies lipid peroxidation, compromising the cell membrane and leading to ferroptosis
