Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)
M.CaputoV.MuqitM
Since the balance is maintained by the presence of adequate amounts of antioxidants, measuring levels of the antioxidants, individually or as total antioxidant capacity (TAC), has also been examined [15, 18, 42, 43]
& Caruso, P
GLP-1 is a hormone produced in the small intestine that stimulates insulin secretion and inhibits glucagon secretion, thereby lowering blood sugar
While semaglutide also causes GI side effects, its single-receptor mechanism (GLP-1 only, versus tirzepatide dual GLP-1/GIP action) produces a different pattern of gastric effects that some people tolerate better
