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These SCFAs cause pro-inflammatory cytokines (such as IL-1 and TNF-), weaken the epithelial barrier, and cause gingival epithelial cells to undergo apoptosis, all of which lead to the deterioration of connective tissue and bone loss

doi: 10.1053/jhep.2002.34939 110 ChenBBaiYTongFYanJZhangRZhongYet al