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The combination of glucagon's direct hepatic effects and GLP-1's metabolic effects makes dual agonists generally superior to pure GLP-1 agonists for hepatic steatosis, supporting potential MASH indications for mazdutide in future regulatory submissions

A few studies also suggest that GLP-1 RAs may increase fertility in men, particularly those with obesity, by improving semen concentration, motility, and morphology

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