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Data on canagliflozin are limited, though one study suggested potential interaction with tadalafil metabolism via cytochrome P450 3A4 inhibition, warranting caution in coadministration [166]

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Furthermore, despite several studies providing interesting data, this association should be interpreted with caution because the majority of these studies did not report or adjusted for the effect of ITB in their survival analyses [24]

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447 Conversely, MSI cancer cells with lower mtDNA copy numbers depended on glycolysis, which contributed to tumorigenesis and cisplatin chemoresistance