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This condition disrupts energy balance, leads to drastic metabolic changes, and causes a notable decrease in fat mass and apparent skeletal muscle atrophy due to perturbing proinflammatory cytokines

Additionally they do not need SUOX SNPs to have this happen (they may have it, but it isnt necessary)

Currently, there are no approved pharmacological treatments for MCI, although MCI is recognized to provide a window of opportunity to address modifiable risk factors and potentially prevent further progression to dementia [6]

2.13.1 APP (amyloid precursor protein) mutations 2.13.1.1 K670N/M671L (Swedish mutation) Cystatin C, a critical secretory cofactor for neurogenesis, possesses strong protease inhibitor activity and plays a significant role in neurological health