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All authors contributed to the interpretation of the data

The condition, called nonarteritic anterior ischemic optic neuropathy, can cause blindness

Psychiatry 63 , 349352 (2008)

Use of XIGDUO XR for this indication is supported by a 26-week placebo-controlled trial of dapagliflozin with a 26-week extension in 157 pediatric patients aged 10 to 17 years with type 2 diabetes mellitus, pediatric pharmacokinetic data, and trials in adults with type 2 diabetes mellitus [see CLINICAL PHARMACOLOGY and Clinical Studies ]

While the loss of significant changes in BCM at week 12 and a rapid increase in body fat between week 6 and 12 was an unexpected finding it might be explained by the underlying progressive tumor disease leading to changes in body composition, irrespective of gain of weight and due to reduced physical activity and progressive sarcopenia

Muscle protein degradation was significantly reduced and muscle protein content was preserved