GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors
These molecules modulate gene expression at transcriptional and post-transcriptional levels, influencing inflammation, oxidative stress, and neuronal repair
Animal data only Scaling a mouse 5 mg/kg dose to a person involves large uncertainty
As GLP-1 therapies scale, the complexity of delivery devices often involving multilayer packaging, elastomeric seals, and polymeric components requires rigorous analytical validation to ensure patient safety and regulatory compliance by identifying and controlling extractables and leachables (E&Ls) that may migrate from device materials into the drug product., Kalathil adds
Perhaps GLP-1 receptor agonists fit the bill as the long awaited holy grail for interventional weight loss
Tirzepatide is newer, but it may lead to greater weight loss for some people because of its dual hormone action