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It is worth noting that this research is longstanding, with some of the earliest studies dating back to 1998
AmericanPsychiatric Association
Last updated: January, 2015
We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes
For patients who already had a substance-use disorder, the pattern was similar
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