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If you lose too much muscle, rebound weight gain can happen quickly when you stop the drug, he explained, stressing the importance of balanced nutrition and regular exercise to maintain muscle mass

However, some peoples digestion systems have slowed down to the point of blockage and paralysis, leading to serious, long-term health issues

On the other hand, some people prefer the simplicity of a once-weekly injection

When your calories drop (especially quickly), your body pulls energy from: Fat Lean tissue (muscle) Research on GLP-1based medications shows that a meaningful portion of weight loss can come from lean mass if protein intake and resistance training arent prioritized

95% CI, 0.92-1.17), the researchers wrote

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41