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Abdominal fat provides convenient systemic administration when local injection proves difficult or for diffuse ankle issues

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CCR2, CCR4, and CCR6 are proven to positively implicate disease activity in RA (113, 114)

That circulating inflammatory load is what connects a digestive problem to symptoms most people would never associate with the gut, which is why repairing the barrier sometimes improves things that seem unrelated

Signal Amplification: Activated receptors trigger G-protein coupling, adenylyl cyclase activation, and dramatic increases in intracellular cAMP (often 10-100 fold elevation)