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As for cadmium-treated cells, we observed a roughly ninefold shift in the LC 50 value for cells lacking SLC39A14 , compared with the control OR1A1 -KO cell line (Fig 3D)

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Studies using rat pinealocytes demonstrated that Epithalon upregulates both arylalkylamine N-acetyltransferase (AANAT) and phosphorylated CREB (pCREB), the rate-limiting enzymes in melatonin synthesis

f , Immunoblot analysis of indicated proteins from SLC33A1 -knockout HEK293T cells expressing a vector control or SLC33A1 cDNA