Detailed observation of the tubules using cryo-EM revealed that the SNX1-SNX2a heterodimer produces a more heterogeneous mix of irregular tubules and spherical vesicles in vitro (Fig
10.1038/s41598-022-20313-5 13 KobayashiK.ToyodaM.KimuraM.HatoriN.FurukiT.SakaiH.et al (2019)
PMID: 38413012
Of course, our study has some limitations, including that most of the included articles showed high bias and heterogeneity which makes it difficult to reach a definitive conclusion about the effects of carnitine
Lim H, Park J, Woo HM (2020) Overexpression of the key enzymes in the methylerythritol 4phosphate pathway in corynebacterium glutamicum for improving farnesyl diphosphate-derived terpene production
As mechanistic insights into iron homeostasis, lipid peroxidation, and immunometabolic interactions continue to deepen, alongside progress in drug delivery, gene editing, and regenerative medicine, therapies targeting ferroptosis may represent a promising new paradigm in OA management, ultimately enhancing joint function and overall quality of life for affected individuals
