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Growth velocity, puberty timing, and bone mineral accrual all add complexity that the adult and adolescent trial programs did not address [3]

Gomez N, Touihri K, Matheeussen V, Mendes Da Costa A, Mahmoudabady M, Mathieu M, Baerts L, Peace A, Lybaert P, Scharpe S, et al: Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure

Raji A, Seely EW, Arky RA, Simonson DC

They directly bind with selectivity to the GLP-1 receptor, causing various beneficial downstream effects that reduce blood glucose in a glucose-dependent fashion

Discordance between ex vivo potency and in vivo PK/PD has many potential causes, one of which, in the case of schistosomicidal agents, is the involvement of the host immune response