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Providers typically exhaust monotherapy optimization, evaluate genetic and biomarker factors, and confirm cardiovascular stability before exploring combination options

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It is present in many lower mammals but absent in humans

*Correspondence: Baptist Gallwitz, [email protected] This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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