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2.18.6 Functional enrichment analysis Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of differentially expressed genes were performed using ClusterProfiler (v3.8.1)

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doi: 10.1038/nature19796 189 CourtneyKDInfanteJRLamETFiglinRARiniBIBrugarolasJet al

In view of the steady market growth of GLP-1RA drugs and prospects of potential expansion to hugely profitable and self-selling indications such as weight management or Parkinsons disease [38], research is urgently needed to clarify the relationship between the use of GLP-1RA and mental health, as well as to identify individuals at a higher risk of suicidal ideation and self-injury

Patients with gout frequently have comorbid conditions that predispose to renal dysfunction and increased urate reabsorption, including hypertension and metabolic syndrome (insulin resistance) (see: Who Gets Gout?) Impaired urinary alkalinization in metabolic syndrome likely contributes to elevated risks of uric acid urolithiasis in the gout patient population

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