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10.1080/1028415X.2015.1135572 Nutr

PubMed ID: 17018654 Raun K et al

This means oral supplementation often requires much higher doses to achieve similar effects

Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO

Mitchell and Anderson, 1994

At the same time, the field acknowledges real limitations heterogeneous trial designs, industry-funded studies, and copper's inherent toxicity at higher concentrations that responsible researchers should factor into any study design