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Despite the concerns of the obesity paradox, weight loss in this population offers several benefits including improved comorbidity management, reduced systemic inflammation, enhanced insulin sensitivity, and optimization for heart transplantation or mechanical support devices in advanced HF [16]

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[1] [2] These results should be interpreted in context: they reflect specific dose groups within obesity cohorts and may not apply across all doses, populations, or indications such as type 2 diabetes

Seminars in Thrombosis and Hemostasis , 2000, 26: 255-61