W., Liu, C
PPAR alpha agonists are responsible primarily for their hypolipidemic effect, while PPAR gamma agonists are antidiabetic agents insulin sensitizers (enhancing insulin mediated glucose uptake and lowering of HbA 1C ), important in the regulation of the lipid metabolism and adipogenesis, and additionally expressed in the vasculature (endothelial cells, smooth muscle cells, and monocyte macrophage cells)
Fatty acids must first be activated (attached to coenzyme A) before entering mitochondria
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These results demonstrate that different drugs that engage the same target have qualitatively and quantitatively distinct signaling fingerprints at the plasma membrane
2024;134(11):e177427