Tirzepatide 2.5 mg activates both GLP-1 and GIP receptors, while semaglutide 0.25 mg activates only GLP-1 receptors
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We are proud to continue advancing innovations that will have a meaningful impact for this patient population, underscoring Novo Nordisk's commitment to cardiometabolic care." CKD affects approximately 37 million adults in the U.S
The individual side effect rates (nausea, vomiting, diarrhea) are similar between the two compounds, but the discontinuation rate, which reflects how many people find the side effects intolerable, is significantly lower for semaglutide (5-7%) compared to retatrutide (12-18%)
However, the absence of hepatic decompensation or overt hepatotoxicity in the ESSENCE trial is reassuring and supports the use of semaglutide in patients with F2-F3 fibrosis, with appropriate monitoring