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Once this interaction is disrupted: p53 is released from the nucleus Cellular self-destruction pathways are activated Senescent cells undergo apoptosis This selective mechanism has made FOXO4-DRI one of the most studied senolytic peptides in modern aging research
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Over a 3-year follow-up, the SURMOUNT-1 trial found that treatment with tirzepatide (a dual GLP1/GIP agonist) of patients with obesity and prediabetes led to substantial and sustained weight reduction, with a lower risk of progression to type 2 diabetes
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Acknowledgements The authors acknowledge the use of AI to support the refinement of the manuscripts language and style
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